Genetic Variations in XRCC2 and XRCC3 Are Not Associated with Endometrial Cancer Risk
نویسندگان
چکیده
منابع مشابه
Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk.
Introduction Endometrial cancer is a component of hereditary nonpolyposis colorectal carcinoma, primarily the consequence of mutations in genes involved in mismatch repair (MMR; MSH2, MLH1, PMS1, and PMS2). In addition to the repair of DNA replication errors, MMR genes have been implicated in homologous recombination repair (HRR) in yeast and in mammalian cells (1, 2). The involvement of the MM...
متن کاملNull Results in Brief Genetic Variations in XRCC2 and XRCC3 Are Not Associated with Endometrial Cancer Risk
Introduction Endometrial cancer is a component of hereditary nonpolyposis colorectal carcinoma, primarily the consequence of mutations in genes involved in mismatch repair (MMR; MSH2, MLH1, PMS1, and PMS2). In addition to the repair of DNA replication errors, MMR genes have been implicated in homologous recombination repair (HRR) in yeast and in mammalian cells (1, 2). The involvement of the MM...
متن کاملPolymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk.
Highly penetrant, but rare, mutations in genes involved in double-strand break repair (i.e., BRCA1 and BRCA2) are associated with a risk for breast cancer of 40% to 65% by age 70 years (1, 2). Polymorphisms in other double-strand break repair genes are thought to contribute to the risk for the disease, either independently or through modifying the risk associated with rare mutations. This study...
متن کاملXRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma.
The XRCC2 and XRCC3 proteins participate in homologous recombination and DNA double-strand break repair to maintain chromosomal stability. Coding-region variants in XRCC2 (Arg188His) and XRCC3 (Thr241Met) have been associated with cancers at several sites (1-3). The XRCC3 241Met homozygous variant has also been associated with increased DNA adduct levels, suggesting a role for this protein in r...
متن کاملGenetic variants in MUTYH are not associated with endometrial cancer risk
Hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an autosomal dominant inherited predisposition to a number of epithelial cancers, most notably colorectal and endometrial cancer. Outside of the context of Lynch syndrome there is little evidence for an autosomal dominant or recessive condition that predisposes to endometrial cancer. Recently, genetic variants ...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2004
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-03-0332